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Products Details
Product Description
– VEGFR-2-IN-36 (compound 15) is a VEGFR-2 inhibitor (IC50: 0.067 μM) and inducer of apoptosis with anticancer activity. VEGFR-2-IN-36 upregulates BAX levels and downregulates Bcl-2 levels. VEGFR-2-IN-36 is toxic to cancer cells, MCF-7 (IC50=0.42 μM) and HepG2 (IC50=0.22 μM)[1].
Web ID
– HY-155242
Shipping
– Room temperature
Molecular Formula
– C24H23N7O5
References
– [1]Eissa IH, et al. Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers. Comput Biol Chem. 2023 Aug 30;107:107953.. .
Molecular Weight
– 489.48
SMILES
– CN(C=N1)C2=C1N(C)C(N(CC(NC3=CC=C(/C(C)=N/NC(C4=CC=C(O)C=C4)=O)C=C3)=O)C2=O)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;VEGFR
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
