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Products Details
Product Description
– VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC50 of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis[1].
Web ID
– HY-144754
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H18N6O2S
References
– [1]Alsaif NA, et al. Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies. Bioorg Med Chem. 2021 Sep 15;46:116384.
CAS Number
– 2839104-01-5
Molecular Weight
– 454.50
SMILES
– O=C(NC1=CC=C(C=C1)C(NC2=CC=CC=C2)=O)CSC3=NC4=C(N5C=NN=C35)C=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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