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Products Details
Product Description
– VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent VEGFR-2 inhibitor with an IC50 of 0.037 µM. VEGFR-2-IN-12 shows high growth inhibition against MCF-7 cells (GI50=1.6 µM). VEGFR-2-IN-12 has antitumor activity[1].
Web ID
– HY-145864
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H24N6O3S
References
– [1]Merve Zengin, et al. Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors. Bioorg Chem. 2022 Apr;121:105696.
Molecular Weight
– 452.53
SMILES
– COC1=CC=C(C=C1)NC(CSC2NN=C(N2C)CN3C(C(C)=NC4=CC=CC=C43)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
