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Products Details
Product Description
– VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis[1].
Web ID
– HY-145856
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H22BrN5S
References
– [1]Abdelrahman Hamdi, et al. Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies. Bioorg Chem. 2022 May;122:105710.
Molecular Weight
– 552.49
SMILES
– S=C(NC1=CC=C(C=C1)NC2=NC(/C=C/C3=CC=C(C=C3)Br)=NC4=CC=CC=C42)NC5=CC=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
