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Products Details
Product Description
– VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential[1].
Web ID
– HY-155464
Shipping
– Room temperature
Molecular Formula
– C20H15ClF6N2O4S
References
– [1]D Shankara S et al. Vetting of New 2, 5-Bis (2, 2, 2-trifluoroethoxy) Phenyl-Linked 1, 3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies[J]. ACS Omega, 2023.
Molecular Weight
– 528.85
SMILES
– FC(F)(F)COC1=C(C(NN2C(C3=CC=C(Cl)C=C3)SCC2=O)=O)C=C(OCC(F)(F)F)C=C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase;VEGFR
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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