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Products Details
Product Description
– VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].
Web ID
– HY-139606
Shipping
– Room temperature
Molecular Formula
– C24H26BN5O4S
References
– [1]Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114.|[2]van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.
CAS Number
– 2630950-38-6
Molecular Weight
– 491.37
SMILES
– O=S(NC1=CC=CC2=C1C=C(C)N2C3=NC(CCC4)=C4C(NCC5=CC(B(O)O)=CC=C5)=N3)(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– p97
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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