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Valiglurax
$90 – $920
Products Details
Product Description
– Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson’s disease[1].
Web ID
– HY-122647
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Molecular Formula
– C16H10F3N5
References
– [1]Panarese JD, et, al. Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease. ACS Med Chem Lett. 2018 Oct 16;10(3):255-260.
CAS Number
– 1976050-09-5
Molecular Weight
– 329.28
Compound Purity
– 98.96
SMILES
– FC(C1=NC=CC2=C1C=CC(NC3=NNC4=NC=CC=C43)=C2)(F)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– mGluR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
