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Product Description
– Valganciclovir-d8 (hydrochloride) is the deuterium labeled Valganciclovir hydrochloride[1]. Valganciclovir hydrochloride, the L-valyl ester of ganciclovir, is actually a proagent for ganciclovir[2][3][4].
Web ID
– HY-A0032AS
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C14H14D8N6O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9.|[3]Chawla JS, et al. Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature. Transpl Infect Dis. 2012 Jun14(3):259-67.|[4]O’Brien S, et al. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood. 2008 Feb 15111(4):1816-9.
CAS Number
– 1132088-63-1
Molecular Weight
– 362.41
SMILES
– [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])[C@@](N)([2H])C(OCC(CO)OCN1C2=C(C(N=C(N2)N)=O)N=C1)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– CMV
Pathway
– Anti-infection
Product type
– Isotope-Labeled Compounds
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