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Products Details
Product Description
– Vabametkib is a potent inhibitor of hepatocyte growth factor receptor (HGFR). Vabametkib inhibits Hs746T cells proliferation and inhibits c-Met with an IC50 value of 7 nM. Vabametkib can be used as an antineoplastic agent[1][2].
Web ID
– HY-148803
Shipping
– Room temperature
Molecular Formula
– C29H34N12O
References
– [1]WHO Drug Information-World Health Organization (WHO).|[2]Jung Hui Jeong, et al. Preparation of triazolopyrazine derivatives as c-Met kinase inhibitors: Korea, Republic of, KR2014022229. 2014-02-24.|[3]WHO Drug Informat ion – World Health Organization (WHO).
CAS Number
– 1571903-56-4
Molecular Weight
– 566.66
SMILES
– CN(N=C1)C=C1C2=CN=C(N=N3)C(N3C[C@@H]4CN(C5=NC=C(C6=CC=C(C=C6)CN7CCN(CC7)C)C=N5)CCO4)=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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