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Products Details
Product Description
– Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines[1].
Web ID
– HY-101870
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H26F3N5O3
References
– [1]Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108.
CAS Number
– 1620012-39-6
Molecular Weight
– 513.51
SMILES
– O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=CN=C4C(CC[C@H]4O)=C3N5C[C@@H](N)[C@H](O)[C@@H](C)C5
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Pim
Isoform
– PIM1;PIM2;PIM3
Pathway
– JAK/STAT Signaling
Product type
– Reference compound
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