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UT-11
$50 – $1,800
Products Details
Product Description
– UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively[1].
Web ID
– HY-149202
Shipping
– Room temperature
Molecular Formula
– C17H19Cl2N3O2S
References
– [1]Sluter MN, et al. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599.
Molecular Weight
– 400.32
SMILES
– O=C(C1CCN(CC1)C2=NC3=C(S2)C=C(C(Cl)=C3)Cl)N[C@@H]4CCOC4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PGE synthase
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
