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Products Details
Product Description
– URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research[1].
Web ID
– HY-153968
Shipping
– Room temperature
Molecular Formula
– C20H13N5O3S
References
– [1]Fengwei Lin, et al. Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase. European Journal of Medicinal Chemistry. Volume 257, 5 September 2023, 115532.
CAS Number
– 2669726-78-5
Molecular Weight
– 403.41
SMILES
– N#CC1=CC(C(C(NC2=C(C(O)=O)N=CS2)=O)=CN3CC4=NC=CC=C4)=C3C=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– URAT1;Xanthine Oxidase
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
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