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UMB-136
SKU
HY-119490-Get quote
Category Reference compound
Tags Anti-infection;Epigenetics, Epigenetic Reader Domain;HIV, Infection
Products Details
Product Description
– UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb[1].
Web ID
– HY-119490
Shipping
– Room temperature
Molecular Formula
– C24H27N5O2
References
– [1]Huang H, et al. A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association. Front Microbiol. 2017 Jun 7;8:1035.
CAS Number
– 2109805-83-4
Molecular Weight
– 417.50
SMILES
– COC1=CC(C2=C(ON=C2C)C)=CC=C1C3=C(N4C(C=NC=C4)=N3)NC5CCCCC5
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain;HIV
Pathway
– Anti-infection;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.