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Products Details
Product Description
– UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb[1].
Web ID
– HY-119490
Shipping
– Room temperature
Molecular Formula
– C24H27N5O2
References
– [1]Huang H, et al. A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association. Front Microbiol. 2017 Jun 7;8:1035.
CAS Number
– 2109805-83-4
Molecular Weight
– 417.50
SMILES
– COC1=CC(C2=C(ON=C2C)C)=CC=C1C3=C(N4C(C=NC=C4)=N3)NC5CCCCC5
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain;HIV
Pathway
– Anti-infection;Epigenetics
Product type
– Reference compound
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