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Products Details
Product Description
– UBP-282 is a potent, selective and competitive AMPA and kainate receptor antagonist. UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC50 value of 10.3 μM. UBP-282 antagonizes kainate-induced depolarisations of dorsal roots with a pA2 value of 4.96[1][2].
Web ID
– HY-19432
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C15H15N3O6
References
– [1]Julia C A More, et al. The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres. Br J Pharmacol. 2002 Dec;137(7):1125-33.|[2]Julia C A More, et al. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br J Pharmacol. 2003 Mar;138(6):1093-100.
CAS Number
– 544697-47-4
Molecular Weight
– 333.30
SMILES
– O=C(O)[C@@H](N)CN(C(N1CC2=CC=C(C(O)=O)C=C2)=O)C=CC1=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Isoform
– AMPA Receptor;Kainate Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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