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Products Details
Product Description
– Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC50=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10)[1].
Web ID
– HY-155240
Shipping
– Room temperature
Molecular Formula
– C23H18ClFN4OS
References
– [1]Zengin Kurt B, et al. Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies. Chem Biol Drug Des. 2023 Aug 31.. .
Molecular Weight
– 452.93
SMILES
– FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=NN=C(NC(NC4=CC(Cl)=CC=C4)=O)S3)=C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Tyrosinase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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