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Products Details
Product Description
– TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].
Web ID
– HY-149892S
Shipping
– Room temperature
Molecular Formula
– C24H21D3FN9O3
References
– [1]Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373.
CAS Number
– 2376999-19-6
Molecular Weight
– 508.52
SMILES
– FC1=CN=C(C2=C(OC)C(NC3=C(C(NC([2H])([2H])[2H])=O)N=NC(NC4=NC=C(C(C)(C)O)C=C4)=C3)=NC=C2)N=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
