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Products Details
Product Description
– TUS-007 is a CANDDY molecular, modified from a proteasome inhibitor. However, TUS-007 hardly inhibits proteasome activity. TUS-007 is also an orally active and potent KRAS G12D/V degrader. TUS-007 can be applied in KRAS G12D/V chemical knockdown in cell-free. TUS-007 also exhibits tumor suppression[1].Note: CANDDY refers to Chemical knockdown with Affinity aNd Degradation DYnamics.
Web ID
– HY-148891
Shipping
– Room temperature
Molecular Formula
– C44H54Cl2N8O5
References
– [1]Imanishi S, et al. In vivo KRAS G12D/V degradation mediated by CANDDY using a modified proteasome inhibitor. bioRxiv, 2021: 2021.04. 23.441075.
CAS Number
– 2227029-18-5
Molecular Weight
– 845.86
SMILES
– O=C(C1=C(C=CC(Cl)=C1)Cl)NCC(N[C@@H](CC(C)C)C(NCCCCCCC(N[C@@H]([C@H](C)CC)C(NC2=CC=C3C(NC(CC4=CNC5=CC=CC=C45)=N3)=C2)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
