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Products Details
Product Description
– Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC50 of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities[1].
Web ID
– HY-146718
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H19NO5Se
References
– [1]Zhu H, Sun H, Liu Y, et al. Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem. 2020;207:112716.
CAS Number
– 2485020-93-5
Molecular Weight
– 420.32
SMILES
– COC1=CC([Se](=O)(/C=C/C2=CC=CC3=C2C=CN3)=O)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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