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Product Description
– Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].
Web ID
– HY-151398
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H20N2O4
References
– [1]Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49(3): 1165-81.
CAS Number
– 2011784-92-0
Molecular Weight
– 340.37
SMILES
– COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
