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Products Details
Product Description
– Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM[1].
Web ID
– HY-147947
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H25N5O3
References
– [1]Wang C, et al. Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles. Bioorg Chem. 2020 Nov;104:103909.
CAS Number
– 2521560-46-1
Molecular Weight
– 407.47
SMILES
– O=C(C1=NN=C(C)N1C2=CC=CC=C2)N3CCN(C4=CC(OC)=CC(OC)=C4)CC3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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