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Products Details
Product Description
– Tubulin polymerization-IN-3 (compound 4c) is a potent tubulin polymerization inhibitor, with an IC50 of 3.84 µM. Tubulin polymerization-IN-3 can induce apoptosis in colon cancer cells[1].
Web ID
– HY-145868
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H20ClN5O3
References
– [1]Mohamed HS, et, al. Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors. Bioorg Chem. 2022 Apr;121:105687.
Molecular Weight
– 413.86
SMILES
– COC1=CC(C2=CC(C3C=CC(Cl)=CC3)=NC4=NC(N)=NN24)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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