Download Files:
Tubulin polymerization-IN-24
$283
Only 1000 item(s) left in stock.
Products Details
Product Description
– Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].
Web ID
– HY-101989
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H16O3
References
– [1]Chatterji BP, et al. HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin. Biochem Pharmacol. 2010 Jul 1;80(1):50-61.
CAS Number
– 564468-51-5
Molecular Weight
– 328.36
SMILES
– O=C1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=CC4=CC=C(OC)C(O)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
