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Products Details
Product Description
– Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells[1].
Web ID
– HY-146311
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H27N5O5
References
– [1]Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846.
CAS Number
– 2296731-38-7
Molecular Weight
– 465.50
SMILES
– COC1=CC(C(C2=NN(N=C2N3CCN(CC3)C(C)=O)C4=CC=CC=C4)=O)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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