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Products Details
Product Description
– Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor with an IC50 of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis[1].
Web ID
– HY-146211
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H15ClN2O2
References
– [1]Shuai W, et al. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. Eur J Med Chem. 2020 Jul 1;197:112308.
CAS Number
– 2417134-05-3
Molecular Weight
– 290.74
SMILES
– C=C(C1=CC(Cl)=NC(NC)=C1)C2=CC=C(C(O)=C2)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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