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Products Details
Product Description
– Tubulin inhibitor 38 (compound 14) is a tetrazole-based Tubulin inhibitor with antiproliferative potencies. Tubulin inhibitor 38 (100 nM，24 h) mediates mitotic arrest，blocks cell cycle at G2/M phase and induces apoptosis. Tubulin inhibitor 38 exhibits high cytotoxicity with high selectivity index among HeLa，MCF7，and U87 MG cells[1].
Web ID
– HY-149376
Shipping
– Room temperature
Molecular Formula
– C17H13ClN6OS
References
– [1]Gallego-Yerga L, et al. Novel Tetrazole Derivatives Targeting Tubulin Endowed with Antiproliferative Activity against Glioblastoma Cells. Int J Mol Sci. 2023 Jul 4;24(13):11093.
Molecular Weight
– 384.84
SMILES
– ClC1=NC(SC)=CC(C2=NN=NN2C3=CC=C(N(C)C=C4C=O)C4=C3)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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