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Product Description
– Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells[1].
Web ID
– HY-115970
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H25N3O4S
References
– [1]Andrés F. Yepes, et al. New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer. Medicinal Chemistry Research volume 30, pages2240–2255 (2021).
Molecular Weight
– 499.58
SMILES
– O=C(C1=CC=C(C=C1)OCCCSC2=NN=C(O2)CCC3=CNC4=C3C=CC=C4)/C=C/C5=CC=CO5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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