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Product Description
– Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells[1].
Web ID
– HY-115970
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H25N3O4S
References
– [1]Andrés F. Yepes, et al. New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer. Medicinal Chemistry Research volume 30, pages2240–2255 (2021).
Molecular Weight
– 499.58
SMILES
– O=C(C1=CC=C(C=C1)OCCCSC2=NN=C(O2)CCC3=CNC4=C3C=CC=C4)/C=C/C5=CC=CO5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
