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Products Details
Product Description
– Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity[1].
Web ID
– HY-143251
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H21N3O4
References
– [1]Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.
CAS Number
– 2883436-66-4
Molecular Weight
– 427.45
SMILES
– COC1=CC=C2N=C(C=C(C2=C1)C(N(CC3=NC=CC=C3)C)=O)C4=CC=C5OCOC5=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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