Download Files:
Products Details
Product Description
– Tubulin/HDAC-IN-3 (compound 12a) is a potent tubulin/HDAC dual inhibitor. Tubulin/HDAC-IN-3 effectively disrupts tubulin polymerization (IC50: 5.4 μM). Tubulin/HDAC-IN-3 exhibits potent HDAC1/8 inhibitory activities, with IC50 values of 0.155 and 0.177 μM, respectively. Tubulin/HDAC-IN-3 works through blocking cellular cycle, inducing apoptosis and inhibiting colony formation[1].
Web ID
– HY-149578
Shipping
– Room temperature
Molecular Formula
– C28H28N2O10
References
– [1]Tang H, et al. Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity. Bioorg Med Chem. 2023 Sep 7;92:117437.
Molecular Weight
– 552.53
SMILES
– O=C1[C@@H](COC(C2=CC=C(C(NO)=O)C=C2)=O)[C@H](C3=CC=C(OC)C(O)=C3)N1C4=CC(OC)=C(OC)C(OC)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;Microtubule/Tubulin
Isoform
– HDAC1;HDAC6;HDAC8
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
