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Products Details
Product Description
– Tubulin/HDAC-IN-1 is a dual tubulin and HDAC-IN-1 inhibitor through CH/Ï€ interaction with tubulin and hydrogen bond interaction with HDAC8. Tubulin/HDAC-IN-1 inhibits tubulin polymerization and selectively inhibits HDAC8 (IC50: 150 nM). Tubulin/HDAC-IN-1 has cytotoxicity against various human cancer cells, also arrests cell cycle in the G2/M phase and induces cell apoptosis. Tubulin/HDAC-IN-1 can be used in the research of hematologic and solid tumors such as neuroblastoma, leukemia[1].
Web ID
– HY-150772
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H18N4O3
References
– [1]Camille Hauguel, et al. Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. Eur J Med Chem. 2022 Jul 1;240:114573.
CAS Number
– 2413587-26-3
Molecular Weight
– 374.39
SMILES
– CN(C1=CC=C(OC)C(/C=C/C(NO)=O)=C1)C2=CC(C#N)=NC3=C2C=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;Microtubule/Tubulin;Mitochondrial Metabolism
Isoform
– HDAC11;HDAC6;HDAC8
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
