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TSHR antagonist S37b
$480 – $3,600
Products Details
Product Description
– TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a (HY-129995A). TSHR antagonist S37b shows only a minor effect for thyrotropin receptor (TSHR) inhibition. TSHR antagonist S37b can be used for the research of thyroid function[1].
Web ID
– HY-129995
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C25H20N2O3S2
References
– [1]Marcinkowski P, et al. A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves’ Orbitopathy. Thyroid. 2019 Jan;29(1):111-123.
CAS Number
– 2143452-22-4
Molecular Weight
– 460.57
Compound Purity
– 99.06
SMILES
– O=C(N1)SC([C@@H]2C3=CC=CC=C3)=C1S[C@]([C@]2([H])[C@]4([H])[C@]56[H])([H])[C@@](C4)([H])[C@@]6([H])C(N(C7=CC=CC=C7)C5=O)=O
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– TSH Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
