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Products Details
Product Description
– TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo[1][2].
Web ID
– HY-136279
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H20AuOPS
References
– [1]Zhang D, et, al. Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J Med Chem. 2014 Oct 9;57(19):8132-9.|[2]Lin YX, et, al. pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy. Mol Pharm. 2015 Aug 3;12(8):2869-78.
CAS Number
– 1527513-89-8
Molecular Weight
– 596.43
SMILES
– COC1=CC=C(C=C1)C#[C-][Au+][P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CS4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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