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Products Details
Product Description
– TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis[1].
Web ID
– HY-157158
Shipping
– Room temperature
Molecular Formula
– C11H12AsCl2NOS2
References
– [1]She W et al. Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy. Biochem Pharmacol. 2023 Nov 4;218:115908.
Molecular Weight
– 384.18
SMILES
– O=C(NC1=CC=C([As]2SCCCS2)C=C1)C(Cl)Cl
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;TrxR
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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