![](https://immunomart.com/wp-content/uploads/2024/05/HY-157131.gif)
Download Files:
TRPV2-selective blocker 1
SKU
HY-157131-Get quote
Category Reference compound
Tags Membrane Transporter/Ion Channel;Neuronal Signaling, Neurological Disease, TRP Channel
Products Details
Product Description
– TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].
Web ID
– HY-157131
Shipping
– Room temperature
Molecular Formula
– C15H18OS2
References
– [1]Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749.
CAS Number
– 2242724-49-6
Molecular Weight
– 278.43
SMILES
– CC(CC(C)/C(C1=CC=CC=C1)=C2SCCS2)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– TRP Channel
Isoform
– TRPV
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.