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Products Details
Product Description
– TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC50s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research[1].
Web ID
– HY-146155
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C21H21N3O
References
– [1]Lili Chen, et al. Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation. Bioorg Med Chem. 2022 May 27;68:116853.
Molecular Weight
– 331.41
SMILES
– CCC1=CC=C(N(CC2=CC=CC=C2)C(NCC3=CC=CO3)=N4)C4=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– TRP Channel
Isoform
– TRPC
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
