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Tropisetron
$32 – $280
Web ID
– HY-B0072
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H20N2O2
References
– [1]Macor JE, et al. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21.|[2]Vega Lde L, et al. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 Aug 1;70(3):369-80.|[3]Stratz C, et al. The anti-inflammatory effects of the 5-HT? receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes. Int Immunopharmacol. 2012 Aug;13(4):398-402.|[4]Candelario-Jalil E, et al. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci. 2008 Feb 6;9:19.
CAS Number
– 89565-68-4
Molecular Weight
– 284.35
Compound Purity
– 98.72
SMILES
– O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– 10 mM in DMSO|10 mM in H2O
Target
– 5-HT Receptor;nAChR
Isoform
– 5-HT3 Receptor
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
