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Tropifexor
$110 – $2,035
Products Details
Product Description
– Tropifexor (LJN452) is a highly potent agonist of FXR with an EC50 of 0.2 nM[1].
Web ID
– HY-107418
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H25F4N3O5S
References
– [1]Tully DC, et al. Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). J Med Chem. 2017 Dec 8.
CAS Number
– 1383816-29-2
Molecular Weight
– 603.58
Compound Purity
– 99.35
SMILES
– FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C(C(O)=O)C=C7S6)[C@H](CC5)C4
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– DMSO : ≥ 80.66 mg/mL
Target
– Autophagy;FXR
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
