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Products Details
Product Description
– TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].
Web ID
– HY-149965
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H17FN4O2
References
– [1]Qiaohua Qin, et al. Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors. Eur J Med Chem. 2023 May 5;253:115291.
CAS Number
– 2924344-29-4
Molecular Weight
– 364.37
SMILES
– COC1=CC=C(C=C1CNC2=CC3=C(NC(/C3=CC4=CN=CN4)=O)C=C2)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Trk Receptor
Isoform
– TrkA;TrkC
Pathway
– Apoptosis;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
