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Products Details
Product Description
– Trk-IN-20 is a kind of 3-vinylindazole derivatives. Trk-IN-20 suppresses Trk kinases functions by phosphorylation inhibition of TrkA/B/C with IC50 values of 1.6 nM, 2.9 nM and 2.0 nM, respectively[1].
Web ID
– HY-150561
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H18F2N4
References
– [1]Duan Y, et al. Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors. Eur J Med Chem. 2020 Oct 1. 203:112552.
CAS Number
– 2460924-63-2
Molecular Weight
– 376.40
SMILES
– FC1=CC([C@@H](C)NC2=CC3=C(C=C2)NN=C3/C=C/C4=NC=CC=C4)=CC(F)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Trk Receptor
Isoform
– TrkA;TrkB;TrkC
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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