Download Files:
Products Details
Product Description
– TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].
Web ID
– HY-144451
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H19ClFN5O3S
References
– [1] Li P, et al. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors [published correction appears in Bioorg Med Chem Lett. 2022 Jan 15;56:128502]. Bioorg Med Chem Lett. 2021;53:128409.
CAS Number
– 2823342-34-1
Molecular Weight
– 439.89
SMILES
– CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Trk Receptor
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
