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Products Details
Product Description
– TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKAG667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers[1].
Web ID
– HY-151945
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H31F3N8O
References
– [1]Xiang S, et, al. Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114899.
CAS Number
– 2904690-41-9
Molecular Weight
– 564.60
SMILES
– CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC([C@@H]3CCN(C3)C4=NN5C(C6=NC=CC=C6)=CN=C5C=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3;RET;Trk Receptor;VEGFR
Isoform
– TrkA;TrkB;TrkC;VEGFR2/KDR/Flk-1
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
