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Products Details
Product Description
– TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC50 values of 2.2, 9.3 and 38 nM towards TRKA, ALKWT and ALKL1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases[1].
Web ID
– HY-144732
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H35ClF2N8O2S
References
– [1]Li T, et al. Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects. Bioorg Med Chem. 2021 Oct 1;47:116396.
Molecular Weight
– 657.18
SMILES
– CN1CCN(CC1)C2=CC=C(C=C2C(N3CCSCC3)=O)NC([C@@H]4CCCN4C5=NC(NC6=CC(F)=CC(F)=C6)=NC=C5Cl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK);Trk Receptor
Isoform
– TrkA
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
