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Trimetrexate (glucuronate)
SKU
HY-103396-Get quote
Category Reference compound
Tags Anti-infection;Cell Cycle/DNA Damage, Antifolate;Bacterial, Cancer; Infection
Products Details
Product Description
– Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia[1][2].
Web ID
– HY-103396
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H33N5O10
References
– [1]R C Jackson, et al. Biochemical pharmacology of the lipophilic antifolate, trimetrexate. Adv Enzyme Regul. 1984;22:187-206.|[2]P J Harris, et al. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. AIDS Patient Care STDS. 1996 Oct;10(5):280-1.
CAS Number
– 82952-64-5
Molecular Weight
– 563.56
SMILES
– O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Antifolate;Bacterial
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
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