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Trimetazidine (dihydrochloride)
$25 – $60
Products Details
Product Description
– Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].
Web ID
– HY-B0968
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H24Cl2N2O3
Citations
– Anatol J Cardiol. 2019 Nov;22(5):232-239.|Mol Cell. 2020 Oct 1;80(1):43-58.e7.|Acta Pharmacol Sin. 2022 Feb 25.|J Pharmaceut Biomed. 2020, 113870.
References
– [1]Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov;3(11):1236-47.|[2]Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4.|[3]Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun;19(5):300-2.|[4]Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8.|[5]Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun;74(9):971-80.
CAS Number
– 13171-25-0
Molecular Weight
– 339.26
Compound Purity
– 99.94
SMILES
– COC1=CC=C(CN2CCNCC2)C(OC)=C1OC.[H]Cl.[H]Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 25 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Target
– Autophagy
Pathway
– Autophagy
Product type
– Reference compound
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