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Products Details
Product Description
– Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
Web ID
– HY-A0061S
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9 13CH11F3 15N2O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.
CAS Number
– 2086328-10-9
Molecular Weight
– 299.18
SMILES
– O=[13C]1[15N](C=C(C([15NH]1)=O)C(F)(F)F)[C@]2([H])O[C@@H]([C@H](C2)O)CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HSV;Nucleoside Antimetabolite/Analog;Orthopoxvirus;Thymidylate Synthase
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
