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Triclosan
$66 – $73
Products Details
Product Description
– Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].
Web ID
– HY-B1119
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H7Cl3O2
References
– [1]Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136.|[2]R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4.|[3]Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107.
CAS Number
– 3380-34-5
Molecular Weight
– 289.54
Compound Purity
– 99.96
SMILES
– OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Antibiotic;Apoptosis;Bacterial;Fungal
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
