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Products Details
Product Description
– TRAP1-IN-2 (compound 36) is a selective TRAP1 client protein degrader, while TRAP1-IN-2 is useless for Hsp90-cytosolic clients. TRAP1-IN-2 also inhibits OXPHOS, alters cellular metabolism towards glycolysis. TRAP1-IN-2 disrupts TRAP1 tetramer stability, and disrupts the mitochondrial membrane potential[1].
Web ID
– HY-155064
Shipping
– Room temperature
Molecular Formula
– C46H42F6N2O5P2
References
– [1]Merfeld T, et al. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur J Med Chem. 2023 Oct 5;258:115531.
Molecular Weight
– 878.77
SMILES
– O=C(C1=C(O)C=CC(C(N2CC(C(OC)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– HSP
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
