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trans-Isoferulic acid
$25 – $50
Products Details
Product Description
– trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].
Web ID
– HY-N0761A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C10H10O4
References
– [1]Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan;18(1):203-11.|[2]Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of <i>Clematis florida var. plena</i>. Nat Prod Res. 2019 Oct;33(20):2925-2931.
CAS Number
– 25522-33-2
Molecular Weight
– 194.19
Compound Purity
– 99.81
SMILES
– O=C(O)/C=C/C1=CC=C(OC)C(O)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NO Synthase;Prostaglandin Receptor
Isoform
– EP;Human Endogenous Metabolite
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
