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Trametinib (DMSO solvate)
SKU
HY-10999A-100 mg
Category Reference compound
Tags Apoptosis;MAPK/ERK Pathway, Apoptosis;MEK, Cancer
$32 – $100
Products Details
Product Description
– Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2].
Web ID
– HY-10999A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H29FIN5O5S
Citations
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December 17, 2021.|Oncol Rep. 2018 Dec; 40(6): 3313–3322.|Oncotarget. 2015 Oct 13;6(31):31313-22. |Oncotarget. 2017 Feb 28;8(9):14835-14846. |Oncotarget. 2020 Nov 3;11(44):3921-3932.|Patent. US20180161326A1.|Patent. US20180169102A1.|Patent. US20180291421A1.|Patent. US20200276189A1.|Patent. US20200291111A1.|Patent. US20200308623A1.|Patent. US20200354680A1.|Patent. US20210008047A1.|Patent. US20210010089A1.|Patent. US20220265657A1.|Patent. US20220372134A1.|Patent. US20230049752A1.|Patent. US20230068698A1.|Patent. US20230158019A1.|Phytomedicine. 2023 Nov 11, 155208.|PLoS Biol. 2020 Jul 17;18(7):e3000778.|Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9570-E9579. |Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4508-4517.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Oct.|Research Square Preprint. 2023 Jul 10.|Research Square Preprint. 2023 May 16.|Research Square Print. October 10th, 2022.|Sci Rep. 2016 Oct 19;6:35531.|Sci Rep. 2017 Mar 28;7:45332.|Sci Rep. 2022 Nov 5;12(1):18811.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Sci Transl Med. 2021 Jan 27;13(578):eaba7308.|SSRN. 2023 Aug 9.|Stem Cell Reports. 2016 Jan 12;6(1):74-84.|Stem Cell Reports. 2017 Dec 12;9(6):1948-1960.|Theranostics. 2022 Oct 3;12(16):7051-7066.|Theranostics. 2020 Feb 18;10(8):3579-3593. |University of California. 2023 Feb.|Viruses. 2021, 13(9), 1758.
References
– [1]Yamaguchi T, et al. Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with HWA486. Inflamm Res, 2012, 61(5), 445-454.|[2]Abe H, et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med Chem Lett. 2011 Feb 28;2(4):320-4.
CAS Number
– 1187431-43-1
Molecular Weight
– 693.53
Compound Purity
– 99.74
SMILES
– CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 3.33 mg/mL (ultrasonic)
Target
– Apoptosis;MEK
Isoform
– MEK1;MEK2
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.