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TR antagonist 1
$550 – $3,950
Products Details
Product Description
– TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
Web ID
– HY-111443
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C25H23Br2NO4
References
– [1]Koehler K, et al. Thyroid receptor ligands. 6. A high affinity “direct antagonist” selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.
CAS Number
– 500794-88-7
Molecular Weight
– 561.26
Compound Purity
– 99.57
SMILES
– O=C(O)CCC1=CC(Br)=C(OC2=CC(/C=C/C3=CC=NC=C3)=C(O)C(C(C)C)=C2)C(Br)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Endocrinology
Solubility
– DMSO : ≥ 83.3 mg/mL
Target
– Thyroid Hormone Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
