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Products Details
Product Description
– TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH)[1].
Web ID
– HY-146997
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C29H25FN2O8
References
– [1]Li Q, et al. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2022;65(10):7193-7211.
CAS Number
– 2770681-85-9
Molecular Weight
– 548.52
SMILES
– O=C(C1=C(C2=CC=C(C=C2C(OC)=N1)OC3=C(C=C(C=C3C)C(C4=CC(OC)=CC(F)=C4)=O)C)O)NCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Thyroid Hormone Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
